Journal
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
Volume 77B, Issue 2, Pages 287-295Publisher
WILEY
DOI: 10.1002/jbm.b.30419
Keywords
polycaprolactone; scaffolds; polymer blends; embryonic stem cells; tissue engineering
Ask authors/readers for more resources
A method of compression-molding fine-powder blends of polycaprolactone (PCL) and poly(ethylene oxide) (PEO) and subsequently dissolving the PEO phase was investigated to prepare porous PCL scaffolds. Different mixing ratios of the two polymers from 20 to 70% PCL were used to study the effect of the mixing ratio on the morphology formation of the scaffold. The mixing ratio was found to play an important role in affecting the porosity of the scaffold and the size of pores. Murine embryonic stem cell derived osteogenic cells were utilized to test the suitability of these scaffolds in tissue engineering applications. The seeded cells were able to colonize and grow in these scaffolds. Based on the overall consideration of morphology, mechanical performance, and ability for cell attachment and proliferation, the scaffolds with approximately 30-40% PCL appear to be an appropriate choice for tissue engineering. These findings suggest that sacrificial compression-molding of PCL-PEO powder blends can be used in the generation of biocompatible scaffolds with controllable porosity and pore size and may he used for in vitro tissue engineering applications. (c) 2005 Wiley Periodicals. Inc.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available