Journal
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
Volume 194, Issue 5, Pages 1316-1322Publisher
MOSBY, INC
DOI: 10.1016/j.ajog.2005.11.059
Keywords
pregnancy; periodontal disease; small-for-gestational-age
Categories
Funding
- NCRR NIH HHS [RR00046] Funding Source: Medline
- NICHD NIH HHS [K08 HD043284] Funding Source: Medline
- NIDCR NIH HHS [R01 DE12453] Funding Source: Medline
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Objective: The objective of the study was to determine whether periodontal disease is associated with delivery of a small-for-gestational-age infant. Study design: In a prospective study of oral health, periodontal disease was categorized as health, mild, or moderate/severe on the basis of clinical criteria. Small for gestational age was defined as birth weight less than the 10th percentile for gestational age. A risk ratio (95th percentile confidence interval) for a small-for-gestational-age infant among women with moderate or severe periodontal disease was calculated. Results: Sixty-seven of 1017 women (6.6%) delivered a small-for-gestational-age infant, and 143 (14.3%) had moderate or severe periodontal disease. The small-for-gestational-age rate was higher among women with moderate or severe periodontal disease, compared with those with health or mild disease (13.8% versus 3.2% versus 6.5%, P < .001). Moderate or severe periodontal disease was associated with a small-for-gestational-age infant, a risk ratio of 2.3 (1.1 to 4.7), adjusted for age, smoking, drugs, marital and insurance Status, and pre-eclampsia. Conclusion: Moderate or severe periodontal disease early in pregnancy is associated with delivery of a small-for-gestational-age infant. Understanding the mechanism of periodontal disease-associated adverse pregnancy outcomes Could lead to interventions to improve fetal growth. (c) 2006 Mosby, Inc. All rights reserved.
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