Journal
CELLULAR AND MOLECULAR LIFE SCIENCES
Volume 63, Issue 9, Pages 1024-1027Publisher
BIRKHAUSER VERLAG AG
DOI: 10.1007/s00018-005-5570-9
Keywords
MET; oncogene; cancer; invasive growth; blood coagulation; haemostasis; PAI-1; COX-2; fibrin
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In human patients, blood coagulation disorders often associate with cancer, even in its early stages. Recently, in vitro and in vivo experimental models have shown that oncogene expression, or inactivation of tumour suppressor genes, upregulate genes that control blood coagulation. These studies suggest that activation of blood clotting, leading to peritumoral fibrin deposition, is instrumental in cancer development. Fibrin can indeed build up a provisional matrix, supporting the invasive growth of neoplastic tissues and blood vessels. Interference with blood coagulation can thus be considered as part of a multifaceted therapeutic approach to cancer.
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