Journal
TETRAHEDRON
Volume 62, Issue 18, Pages 4435-4443Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2006.02.062
Keywords
amination; phosphoramidite; heteroaryl bromide; copper; catalysis
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A highly efficient copper-catalyzed system using phosphoramidite as ligands was applied to N-arylation of alkylamines and N(H)-heterocycles with aryl iodides and heteroaryl bromides. The reactions were carried out in relative mild conditions and good to excellent yields were obtained. (c) 2006 Elsevier Ltd. All rights reserved.
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