Journal
JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC
Volume 39, Issue 1-4, Pages 45-49Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.molcatb.2006.01.025
Keywords
lipase; kinetic resolution; desymmetrization; phosphine P-boranes; chirality
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Enantiomerically enriched alkoxy(hydroxymethyl)phenylphosphine boranes were obtained via a lipase-catalyzed acetylation performed under kinetic resolution conditions. The reaction was slow and proceeded with a rather low enantioselectivity. A lipase-catalyzed acetylation of prochiral bis(2-hydroxyethyl)phenylphosphine borane resulted in its desymmetrization and gave the enantiomerically enriched monoacetyl derivative with ee up to 90%. (c) 2006 Elsevier B.V. All rghts reserved.
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