Journal
NEURON
Volume 50, Issue 3, Pages 353-357Publisher
CELL PRESS
DOI: 10.1016/j.neuron.2006.04.020
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Funding
- NIGMS NIH HHS [R01 GM072778] Funding Source: Medline
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Prion diseases in humans and animals are due to conformational conversion of PrPC, a cellular glycoprotein of unknown function, into PrPSc, an isoform that appears to be infectious in the absence of nucleic acids. Proteins that behave as prions are also found in yeast and filamentous fungi. Although there is now strong experimental support for the hypothesis that prions are infectious proteins, two subjects have remained poorly understood: the structure of prions, and the mechanisms by which they kill neurons. In this review, we will highlight recent studies that shed new light on these important issues.
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