No association between chronic musculoskeletal complaints and Val158Met polymorphism in the Catechol-O-methyltransferase gene. The HUNT study

Background: The Catechol-O-methyltransferase (COMT) gene contains a functional polymorphism, Val158Met, that has been found to influence human pain perception. In one study fibromyalgia was less likely among those with Val/Val genotype. Methods: In the 1995 - 97 Nord-Trondelag Health Study (HUNT), the association between Val/ Met polymorphism at the COMT gene and chronic musculoskeletal complaints (MSCs) was evaluated in a random sample of 3017 individuals. Results: The distribution of the COMT Val158Met genotypes and alleles were similar between controls and the twelve different chronic MSCs groups. Even when the Met/Met and Val/ Met genotypes were pooled, the distribution of the Val/ Val genotype and other genotypes were similar between controls and the chronic MSCs groups. Conclusion: In this population-based study, no significant association was found between Val/ Met polymorphism at the COMT gene and chronic MSCs.