Journal
CANCER LETTERS
Volume 236, Issue 1, Pages 46-53Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2005.05.010
Keywords
thioredoxin reductase; apoptosis; cellular sensitivity; Bcl-2/Bax; caspase-3
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Human thioredoxin reductase (TrxR) system is associated with cancer cell growth and anti-apoptosis process. Effects of 1, 2[his (1,2-Benzisoselenazolone-3 (2H)-ketone)]ethane (BBSKE), a novel TrxR inhibitor, were investigated on A549, HeLa, Bel-7402, BGC823 and KB cell lines. After treated with BBSKE, a good linear correlation coefficient (r >= 0.989) between TrxR activity and cell viability exists in each cell line together with cell growth/proliferation inhibition and apoptosis through Bcl2/Bax and Caspase-3 pathways. These results suggest that there exists some relationship between TrxR inactivation and growth/proliferation inhibition or apoptosis in the investigated cell lines. (c) 2005 Elsevier Ireland Ltd. All rights reserved.
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