Journal
TETRAHEDRON LETTERS
Volume 47, Issue 19, Pages 3229-3232Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2006.03.048
Keywords
Pseudopterogorgia elisabethae; tuberculosis; Caribbean gorgonian octocorals; ileabethane skeleton; benzoxazole; mycobacterium
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Ileabethoxazole (1), a new perhydroacenaphthene-type diterpene alkaloid containing the uncommon benzoxazole moiety, was isolated from the Caribbean sea whip Pseudopterogorgia elisabethae. The structure of I was elucidated by extensive spectroscopic data interpretation. Ileabethoxazole showed 92% inhibition of Mycobacterium tuberculosis (H(37)Rv) at the concentration range of 128-64 mu g/mL. (c) 2006 Elsevier Ltd. All rights reserved,
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