Journal
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
Volume 597, Issue 1-2, Pages 113-118Publisher
ELSEVIER
DOI: 10.1016/j.mrfmmm.2005.12.001
Keywords
bystander effect; genomic instability; DNA repair; genetic susceptibility; gap junction intercellular communication; oxidative stress
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This report reviews briefly some of the findings reported over the past 2 years that enhance our understanding of the radiation-induced bystander effect. These developments include: technicological advances; the role of oxidative stress; the effect of cytoplasmic irradiation; cell-to-cell communication; and evidence that Connexin 43 mediated intercellular communication is induced by radiation exposure. A few overriding unanswered questions are discussed. These include: what is the signal(s) transmitted from irradiated to bystander cells; what is the relationship between the bystander response and other non-targeted effects of radiation; are there beneficial effects associated with the bystander response; and what is the significance of the bystander effect for radiation protection? (c) 2005 Elsevier B.V. All rights reserved.
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