Journal
PHYSICAL REVIEW LETTERS
Volume 96, Issue 18, Pages -Publisher
AMER PHYSICAL SOC
DOI: 10.1103/PhysRevLett.96.188101
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Genetic switch systems with mutual repression of two transcription factors are studied using deterministic and stochastic methods. Numerous studies have concluded that cooperative binding is a necessary condition for the emergence of bistability in these systems. Here we show that, for a range of biologically relevant conditions, a suitable combination of network structure and stochastic effects gives rise to bistability even without cooperative binding.
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