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Synthesis of enantiopure 1-azaspiro[4.5]dec-6-en-8-ones from L-proline derivatives

Journal

TETRAHEDRON-ASYMMETRY
Volume 17, Issue 9, Pages 1437-1443

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetasy.2006.05.002

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An enantioselective synthesis of protected 1-azaspiro[4.5]dec-6-en-8-one derivatives was achieved using an alkylidene carbene 1,5-CH insertion reaction as the key step. (c) 2006 Elsevier Ltd. All rights reserved.

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