Journal
FEBS LETTERS
Volume 580, Issue 11, Pages 2677-2685Publisher
WILEY
DOI: 10.1016/j.febslet.2006.04.021
Keywords
amphotericin B; biomembranes; polyene antibiotics; lipid membranes; ergosterol; cholesterol
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The H-1 NMR technique was applied to study binding of AmB, an antifungal drug, to lipid membranes formed with egg yolk phosphatidylcholine. The analysis of H-1 NMR spectra of liposomes, containing also cholesterol and ergosterol (at 40 mol%), shows that AmB binds preferentially to the polar headgroups. Such a binding restricts molecular motion of the choline fragment in the hydrophilic region at the surface of liposomes but increases the segmental motional freedom in the hydrophobic core. The same effects are also observed in the sterol-containing membranes, except that the effect on the hydrophobic core was exclusively observed in the membranes containing ergosterol. (c) 2006 Published by Elsevier B.V. on behalf of the Federation of European Biochemical Societies.
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