Journal
ANNALS OF ONCOLOGY
Volume 25, Issue 4, Pages 912-913Publisher
OXFORD UNIV PRESS
DOI: 10.1093/annonc/mdu041
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Lapatinib is able to penetrate brain metastases from HER2-positive breast cancer. We assessed lapatinib concentration in cerebrospinal fluid (CSF) of two patients with HER2-positive metastatic breast cancer and brain metastases, and we found low levels of the drug in CSF of both patients. Lapatinib concentration in CSF may not be a reliable surrogate of its distribution in brain metastases.
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