Journal
BIOINFORMATICS
Volume 22, Issue 10, Pages 1166-1171Publisher
OXFORD UNIV PRESS
DOI: 10.1093/bioinformatics/btl073
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Motivation: Amino acid changing mutations in proteins are contstrained by purifying selection and accumulate at different rates. We estimate evolutionary rates on multiple alignments of eukaryotic protein families in a maximum likelihood framework and spot sets of slow and fast evolving proteins. Results: We find that the evolution of indispensable proteins is constrained by selection and that protein secretion is coupled to an increased evolutionary rate.
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