Journal
NEUROREPORT
Volume 17, Issue 7, Pages 705-709Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/01.wnr.0000215769.71657.65
Keywords
angiogenesis; Flt-I neurogenesis; Flk-I; Parkinson's disease; vascular endothelial growth factor
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Recently, we confirmed the presence of enhanced neural reconstruction in Parkinson's disease and in an animal model of Parkinson's disease based on increased polysialic acid-like immunoreactivity. Changes in neurogenesis often appear parallel to changes in angiogenesis. Moreover, both these processes share similar modulating factors, like vascular endothelial growth factor (VEGF) and its receptors VEGFR-I (Flt-1) and VEGFR-2 (Flk-1). Using immunohistochemistry, we identified in this study upregulation of VEGF in the substantia nigra but not in the striatum of patients with Parkinson's disease by enzyme-linked immunosorbent assay. Such overexpression may participate in vascular remodeling and neurogenesis in the substantia nigra of Parkinson's disease.
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