Journal
JOURNAL OF IMMUNOLOGY
Volume 176, Issue 10, Pages 5880-5889Publisher
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.176.10.5880
Keywords
-
Categories
Funding
- NIAID NIH HHS [P01 AI 35296, P01 AI 050162] Funding Source: Medline
- NIGMS NIH HHS [R01 GM 54706] Funding Source: Medline
Ask authors/readers for more resources
T cell clonal anergy induction in lymphopenic nu/nu mice was found to be ineffective. Exposure to a tolerizing peptide Ag regimen instead induced aggressive CD4(+) cell cycle progression and increased Ag responsiveness (priming). Reconstitution of T cell-deficient mice by an adoptive transfer of mature peripheral lymphocytes was accompanied by the development of a CD25(+)Foxp3(+)CTLA-4(+)CD4(+) regulatory T cell population that acted to dampen Ag-driven cell cycle progression and facilitate the induction of clonal anergy in nearby responder CD25(-)CD4(+) T cells. Thus, an early recovery of CD25(+) regulatory T cells following a lymphopenic event can prevent exuberant Ag-stimulated CD4(+) cell cycle progression and promote the development of clonal anergy.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available