Transition metal-catalyzed C-C bond formation reactions using alkyl halides

This account reviews transition metal-catalyzed C-C bond formation reactions using alkyl halides, which have rarely been used as carbon sources in conventional transition metal-catalyzed systems. In the reactions, ate complexes formed by the reaction of transition metals with a Grignard reagent play important roles as the active catalytic species. The reactions mentioned here are mechanistically new and provide a promising methodology for the construction of carbon frameworks employing alkyl halides.