Journal
TETRAHEDRON LETTERS
Volume 47, Issue 20, Pages 3383-3386Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2006.03.085
Keywords
ketone; diketone; aldol reaction; asymmetric; proline
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The direct aldol reaction of 1,2-diketones and ketones mediated by proline derivatives yields the corresponding 2-hydroxy 1,4-diketones in high regioselectivity, diastereoselectivity and good enantioselectivity. This reaction provides an easy access to optically active tertiary alcohols, which are flanked by two carbonyl groups for further elaborations. (c) 2006 Elsevier Ltd. All rights reserved.
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