Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 103, Issue 20, Pages 7660-7663Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0602012103
Keywords
cytoskeleton; dynamics; membrane tethers
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We discuss the pulling force f required to extrude a lipid tube from a living cell as a function of the extrusion velocity L The main feature is membrane friction on the cytoskeleton. As recently observed for neutrophils, the tether force exhibits a shear thinning response over a large range of pulling velocities, which was previously interpreted by assuming viscoelastic flows of the sliding membrane. Here, we propose an alternative explanation based on purely Newtonian flow: The diameter of the tether decreases concomitantly with the increase of the membrane tension in the lipid tube. The pulling force is found to vary as L-1/3, which is consistent with reported experimental data for various types of cells.
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