Journal
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
Volume 54, Issue 10, Pages 3744-3749Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jf0601113
Keywords
hydroxymethylfurfural; prunes; human subjects
Ask authors/readers for more resources
5-( Hydroxymethyl)- 2- furfural ( I) is a major breakdown product occurring in solutions with high concentrations of fructose and glucose and is present in many fruit juices, in heat- sterilized parenteral solutions, and in baby cereals. The objective of this study was to characterize and identify 5-( hydroxymethyl)- 2- furfural metabolites in human subjects following the consumption of dried plum juice and/ or dried plums. Subjects were fasted overnight and blood and urine samples were obtained during the day following consumption. Subjects fed the dried plum juice and dried plums consumed 3944 mu mol ( 497 mg) and 531 mu mol ( 67 mg) of I, respectively. Four presumed metabolites of I were detected in the urine of subjects that consumed dried plum juice. They were tentatively identified using HPLC- MS/ MS as ( 1) N- ( 5- hydroxymethyl- 2- furoyl) glycine ( III), ( 2) 5- hydroxymethyl- 2- furoic acid ( II), ( 3) ( 5- carboxylic acid- 2- furoyl) glycine ( IV), and ( 4) ( 5- carboxylic acid- 2- furoyl) aminomethane ( V). Total urinary excretion during the 6 h following the consumption of dried plum juice was 168, 1465, 137, and 75 mu moles on the basis of II as a standard for II, III, IV, and V, respectively. The estimated total recovery of I metabolites was 46.2% and 14.2% of the I dose during the first 6 h after consumption of dried plum juice and dried plums, respectively. I seems to be metabolized rapidly to glycine conjugates and other metabolites and excreted in the urine.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available