Journal
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
Volume 54, Issue 10, Pages 3750-3755Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jf0531712
Keywords
Kazunoko; n-3 polyunsaturated fatty acid; cholesterol; plasma lipids; plasma glucose; insulin; adiponectin
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The aim of this study was to evaluate the effects of dietary Kazunoko ( salted herring roe) lipids, which contain large amounts of cholesterol, phosphatidylcholine, and n- 3 polyunsaturated fatty acids, such as eicosapentaenoic acid ( EPA, 20: 5n- 3) and docosahexaenoic acid ( DHA, 22: 6n- 3), on lipid and glucose metabolism in mice. Male Crlj: CD- 1 ( ICR) mice were fed one of four experimental diets which contained 6% lard, 1% Kazunoko lipids + 5% lard, 3% Kazunoko lipids + 3% lard, and 6% Kazunoko lipids for 12 weeks. Plasma total cholesterol, triacylglycerol, phospholipid, and glucose concentrations were significantly lower in the 3% and 6% Kazunoko lipid diet groups than in lard and 1% Kazunoko lipid diet groups ( p < 0.05). Plasma adiponectin concentrations of mice fed the 6% Kazunoko lipid diet were higher than those of animals fed the lard diet group. These results suggest that EPA and DHA rather than cholesterol in the Kazunoko lipids influence the plasma total cholesterol level. The constituent Kazunoko lipids may not only decrease the levels of plasma lipids but also decrease glucose concentrations by enhancing plasma adiponectin levels in mice.
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