Journal
NATURAL PRODUCT RESEARCH
Volume 20, Issue 6, Pages 578-585Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786410500185253
Keywords
Smenospongia sp.; aureol derivatives; cytotoxicity
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The sesquiterpene aureol ( 1) was isolated by chromatographic fractionation of a non-polar extract from Smenospongia sp. Methylation of aureol yielded 5'-O-methyl-aureol ( 2) while the prepared acylation products of aureol were 5'-O-acetyl-aureol ( 3), 5'-O-benzoyl-aureol ( 4), 5'-O-(4-fluoro-benzoyl)-aureol ( 5), 5'-O-(4-chlorobenzoyl)-aureol ( 6), 5'-O-( 4- methylbenzoyl)aureol ( 7), 5'-O- nicotinoyl- aureol ( 8), aureol-N,N-dimethylthiocarbamate ( 9), 5'-O-( 2-furoylcarbonyl)aureol ( 10), 5'-O-(2-thienoylcarbonyl- aureol ( 11). The structures of aureol as well as its ten derivatives were established through spectral analysis. The in vitro cytotoxic activities of the eleven compounds were evaluated against Hepa59T/VGH, KB and Hela tumor cell lines.
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