Journal
WORLD JOURNAL OF GASTROENTEROLOGY
Volume 12, Issue 19, Pages 2991-2999Publisher
BAISHIDENG PUBLISHING GROUP INC
DOI: 10.3748/wjg.v12.i19.2991
Keywords
Helicobacter pylori; gastric cancer; meta-analysis; systematic review
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Since the discovery of Campylobacter-like organisms (Helicobacter pylori) more than two decades ago the possibility of a relationship with gastric cancer has been postulated, tested and supposedly proven. There have been numerous human studies of various designs from many countries around the world. Several meta-analyses have been published and more recently a small number of experimental animal studies were reported looking at the association between Helicobacter pylori infection and gastric cancer. Over the years, the human epidemiological studies have produced conflicting results; the meta-analyses have as one would expect produced similar pooled estimates; while the early experimental animal studies require replication. The exact mechanisms by which H pylori might cause gastric cancer are still under investigation and remain to be elucidated. (c) 2006 The WJG Press. All rights reserved.
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