Journal
FEBS LETTERS
Volume 580, Issue 12, Pages 2879-2887Publisher
WILEY
DOI: 10.1016/j.febslet.2006.03.087
Keywords
VEGF; angiogenesis; signaling; diseases
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Angiogenesis is the process by which new blood vessels are formed from existing vessels. The vascular endothelial growth factors (VEGFs) are considered as key molecules in the process of angiogenesis. The VEGF family currently includes VEGF-A, -B, -C, -D, -E, -F and placenta growth factor (PIGF), that bind in a distinct pattern to three structurally related receptor tyrosine kinases, denoted VEGF receptor-1, -2, and -3. VEGF-C and VEGF-D also play a crucial role in the process of lymphangiogenesis. Here, we review the biology of VEGFs and evaluate their role in pathological angiogenesis and lymphangiogenesis. (c) 2006 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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