Journal
VACCINE
Volume 24, Issue 21, Pages 4503-4509Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2005.08.017
Keywords
DNA; electroporation; vaccine; HIV
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Funding
- NIAID NIH HHS [N01-AI-05396] Funding Source: Medline
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A plasmid DNA vaccine containing a fusion gene consisting of an HIV-1 subtype C gag and a modified subtype C pol was compared to a mixture of gag plus pol or gag plus HIV env plasmids. Plasmid DNA was delivered by intramuscular injection followed by electroporation in vivo. Two vaccinations were sufficient to induce high levels of Gag- and Pol-specific CD4 and CD8 T cells in peripheral blood. The gag-pol fusion plasmid was as immunogenic as the plasmid mixtures. Thus, DNA vaccination by intramuscular electroporation was an effective means for inducing high levels of Gag- and Pol-specific T cells, and a single gag-pol fusion DNA vaccine was sufficient for eliciting immune responses against both antigens. (c) 2005 Published by Elsevier Ltd.
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