Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 103, Issue 21, Pages 8090-8095Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0601083103
Keywords
infertility; oocyte; ovary; reproduction; folliculogenesis
Categories
Funding
- NICHD NIH HHS [F32 HD046335, HD44858, 5F32 HD46335-01A1, R01 HD044858, HD42500, R01 HD042500] Funding Source: Medline
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Mammalian oogenesis requires oocyte-specific transcriptional regulators. The full complement of oocyte-specific transcription factors is unknown. Here, we describe the finding that Sohlh1, a spermatogenesis and oogenesis basic helix-loop-helix transcription factor in females, is preferentially expressed in oocytes and required for oogenesis. Sohlh1 disruption perturbs follicular formation in part by causing down-regulation of two genes that are known to disrupt folliculogenesis: newborn ovary homeobox gene (Nobox) and factor in the germ-line alpha (Figla). In addition, we show that Lhx8 is downstream of Sohlh1 and critical in fertility. Thus, Sohlh1 and Lhx8 are two germ cell-specific, critical regulators of oogenesis.
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