Journal
FEBS LETTERS
Volume 580, Issue 13, Pages 3315-3320Publisher
WILEY
DOI: 10.1016/j.febslet.2006.04.092
Keywords
endosperm-specific expression; glutelin; transgenic rice; hypertension; Oryza sativa
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RPLKPW is a potent anti-hypertensive peptide designed according to the structure of ovokinin(2-7) (RADHPF). In this study, we generated transgenic rice plants that accumulate the RPLKPW peptide as a fusion protein with the rice storage protein glutelin. The engineered peptide is expressed under the control of endosperm-specific glutelin promoters and specifically accumulates in seeds. Oral administration of either the RPLKPW-glutelin fraction or transgenic rice seeds to spontaneously hypertensive rats (SHRs) significantly reduced systolic blood pressures. These results suggest the possible application of transgenic rice seed as a nutraceutical delivery system and specifically for administration of active peptides in hypertension. (c) 2006 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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