Journal
FEBS LETTERS
Volume 580, Issue 13, Pages 3296-3300Publisher
WILEY
DOI: 10.1016/j.febslet.2006.05.005
Keywords
plenty of SH3s; apoptosis-linked gene-2; ALG-2-interacting protein X; c-Jun N-terminal kinase; cell death
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Plenty of SH3s (POSH) functions as a scaffold protein for the Jun N-terminal kinase (JNK) signal transduction pathway, which leads to cell death in mammalian cultured cells and Drosophila. Here, we show that POSH forms a complex with Apoptosis-linked gene-2 (ALG-2) and ALG-2-interacting protein (ALIX/AIP1) in a calcium-dependent manner. Overexpression of ALG-2 or ALIX in developing imaginal eye discs resulted in roughened or melanized eyes, respectively. These phenotypes were enhanced by co-overexpression of POSH. We found that overexpression of either gene could induce ectopic JNK activation, suggesting that POSH/ALG-2/ALIX may function together in the regulation of the JNK pathway. (c) 2006 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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