Journal
JOURNAL OF IMMUNOLOGICAL METHODS
Volume 312, Issue 1-2, Pages 34-39Publisher
ELSEVIER
DOI: 10.1016/j.jim.2006.02.009
Keywords
natural killer T cell; T cell receptor; alpha-galactosyl ceramide; cytokine
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Funding
- NIAID NIH HHS [P01 AI053725, F32 AI62015] Funding Source: Medline
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CD1d presentation of alpha-galactosyl ceramides to natural killer T cells has been a focal point of the study of regulatory T cells. KRN7000, an alpha-galactosyl ceramide originally generated from structure activity studies of antitumor properties of marine sponge glycolipids, is currently the most commonly used agonist ligand and is used to stain NKT cells, However, this glycolipid suffers from poor solubility and availability. We have developed an alpha-galactosyl ceramide with improved solubility over KRN7000 that effectively stains NKT cells, both mouse and human, and stimulates cytokine release at low concentrations. (c) 2006 Elsevier B.V. All rights reserved.
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