Journal
JOURNAL OF NEUROSCIENCE
Volume 26, Issue 22, Pages 5881-5887Publisher
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.0323-06.2006
Keywords
addiction; relapse; memory reconsolidation; basolateral amygdala; antisense oligodeoxynucleotides; rat
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Funding
- Medical Research Council [G0600196, G0001354, G9537855, G0001354B] Funding Source: researchfish
- MRC [G9537855, G0600196] Funding Source: UKRI
- Medical Research Council [G9537855, G0001354, G0600196] Funding Source: Medline
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Long-lasting vulnerability to drug cue-induced relapse to a drug-taking habit is a major challenge to the treatment of drug addiction. Here we show that blockade of drug memory reconsolidation, through infusion of Zif268 antisense oligodeoxynucleotides into the basolateral amygdala shortly before reexposure to a cocaine-associated stimulus but not simply to the training context, severely impaired subsequently cue-maintained cocaine seeking under a second-order schedule of reinforcement and abolished cue-induced reinstatement of and relapse to cocaine seeking. This reduction in relapse after disrupted memory reconsolidation was not only seen after several hundred pairings of the stimulus with self-administered cocaine, but older, as well as recent, memories were also disrupted. Reconsolidation blockade may thus provide a potential therapeutic strategy for the prevention of relapse in drug addiction.
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