Journal
BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM
Volume 20, Issue 2, Pages 193-205Publisher
BAILLIERE TINDALL
DOI: 10.1016/j.beem.2006.02.005
Keywords
epidemiology; polycystic ovary syndrome; phenotyping; complex disorders
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Funding
- NICHD NIH HHS [K24-HD01346-01] Funding Source: Medline
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Polycystic ovary syndrome (PCOS) is a heterogeneous disorder, and its definition remains fluid and controversial. PCOS is characterized by clinical and/or biochemical hyperandrogenism, and is frequently accompanied by ovulatory dysfunction and polycystic ovaries. PCOS is a diagnosis of exclusion, with other androgen excess and related disorders to be excluded. The prevalence of PCOS is 6.5-8.0% of unselected women of reproductive age, using the NIH 1990 criteria. Genetically, PCOS is a common, complex disorder. Despite repeated attempts to identify the putative gene or genes responsible for this disorder, the PCOS gene(s) remain elusive.
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