Journal
LEUKEMIA
Volume 20, Issue 6, Pages 979-986Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.leu.2404203
Keywords
acute myeloid leukemia; fibroblast growth factor; fibroblast growth factor receptor; cell signaling; chemotherapy; animal studies
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Fibroblast growth factors (FGFs) are important regulators of hematopoiesis and have been implicated in the tumorigenesis of solid tumors. Recent evidence suggests that FGF signaling through FGF receptors (FGFRs) may play a role in the proliferation of subsets of acute myeloid leukemias (AMLs). However, the precise mechanism and specific FGF receptors that support leukemic cell growth are not known. We show that FGF-2, through activation of FGFR1 ss signaling, promotes survival, proliferation and migration of AML cells. Stimulation of FGFR1 ss results in phosphoinositide 3-kinase (PI3-K)/Akt activation and inhibits chemotherapy-induced apoptosis of leukemic cells. Neutralizing FGFR1-specific antibody abrogates the physiologic and chemoprotective effects of FGF-2/FGFR1 ss signaling and inhibits tumor growth in mice xenotransplanted with human AML. These data suggest that activation of FGF-2/FGFR1 ss supports progression and chemoresistance in subsets of AML. Therefore, FGFR1 targeting may be of therapeutic benefit in subsets of AML.
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