Journal
CHEMICAL & PHARMACEUTICAL BULLETIN
Volume 54, Issue 6, Pages 882-883Publisher
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/cpb.54.882
Keywords
Microsporum sp.; asperflavin ribofuranoside; flavoglaucin; isodihydroauroglaucin; citrinin; radical scavenging activity
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A new anthracene glycoside, asperflavin ribofuranoside (1), and the previously described polyketides, flavoglaucin (2), isodihydroauroglaucin (3), and citrinin (4) have been isolated from the marine-derived fungus Microsporum sp. The structure and absolute stereochemistry of a new compound (1) was assigned on the basis of physicochemical data. Compounds 1-3 exhibited a significant radical scavenging activity against 1,1-diphenyl-2-picrylhydrazyl (DPPH) with IC50 values of 14.2, 11.3, and 11.5 mu m, respectively, which are more potent than the positive control, ascorbic acid (IC50, 20 mu m). Compound 1 also showed a moderate antibacterial activity against the methicillin-resistant and multidrug-resistant Staphylococcus aureus (MRSA and MDRSA) with MIC value of 50 mu g/ml.
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