Journal
AQUATIC TOXICOLOGY
Volume 78, Issue -, Pages S105-S108Publisher
ELSEVIER
DOI: 10.1016/j.aquatox.2006.02.023
Keywords
micronuclei; mussells; bisphenol A; diallyl phthalate; tetrabromodiphenyl ether-47
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Analysis of micronuclei. nuclear buds, bi-polynucleated and fragmented-apoptotic cells was performed in gills of blue mussels exposed for 3 weeks to sublethal concentrations of bisphenol A, diallyl phthalate (for the both nominal concentration 50ppb) and to tetrabromodiphenyl ether-47 (nominal concentration 5 ppb). Fourteen specimens from each treatment and control group were used for the analysis. Our results demonstrated a significant increase in micronuclei frequency after the treatment with bisphenol A (P = 0.0243), diallyl phthalate (P = 0.0005) and tetrabromodiphenyl ether-47 (P < 0.0001; Mann-Whitney U-test). Induction of bi-nucleated (P = 0.0028), fragmented-apoptotic (P = 0.0004) cells and nuclear buds (P = 0.0101) was found in Mussels exposed to tetrabromodiphenyl ether-47 while treatment with diallyl phthalate increased the level of fragmented-apoptotic cells (P = 0.0283). Bisphenol A was the only agent that resulted only in induction of micronuclei but not any other kind of nuclear injuries. (c) 2006 Elsevier B.V. All rights reserved.
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