Journal
DEVELOPMENT
Volume 133, Issue 11, Pages 2149-2154Publisher
COMPANY BIOLOGISTS LTD
DOI: 10.1242/dev.02381
Keywords
mouse; Dkk2; cornea; epidermis; differentiation; Wnt/beta-catenin
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Funding
- Intramural NIH HHS Funding Source: Medline
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The Dkk family of secreted cysteine-rich proteins regulates Wnt/beta-catenin signaling by interacting with the Wnt co-receptor Lrp5/6. Here, we show that Dkk2-mediated repression of the Wnt/beta-catenin pathway is essential to promote differentiation of the corneal epithelial progenitor cells into a non-keratinizing stratified epithelium. Complete transformation of the corneal epithelium into a stratified epithelium that expresses epidermal-specific differentiation markers and develops appendages such as hair follicles is achieved in the absence of the Dkk2 gene function. We show that Dkk2 is a key regulator of the corneal versus epidermal fate of the ocular surface epithelium.
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