Journal
JOURNAL OF MEDICINAL FOOD
Volume 9, Issue 2, Pages 281-283Publisher
MARY ANN LIEBERT, INC
DOI: 10.1089/jmf.2006.9.281
Keywords
acetylcholinesterase; ascorbic acid; Glycyrrhiza glabra; metrifonate; Myristica fragrans
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The central cholinergic pathways play a prominent role in the learning and memory processes. Acetylcholinesterase is an enzyme that inactivates acetylcholine. The present study was undertaken to estimate the acetylcholinesterase-inhibiting activity of extracts of Glycyrrhiza glabra, Myristica fragrans seeds, and ascorbic acid and compare these values with a standard acetylcholinesterase-inhibiting drug, metrifonate. Aqueous extract of G. glabra (150 mg/kg p.o. for 7 successive days), n-hexane extract of M. fragrans seeds (5 mg/kg p.o. for 3 successive days), ascorbic acid (60 mg/kg i.p. for 3 successive days), and metrifonate (50 mg/kg i.p.) were administered to young male Swiss albino mice. Acetylcholinesterase enzyme was estimated in brains of mice. G. glabra, M. fragrans, ascorbic acid, and metrifortate significantly decreased acetylcholinesterase activity as compared with their respective vehicle-treated control groups.
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