Journal
THERAPEUTIC DRUG MONITORING
Volume 28, Issue 3, Pages 295-298Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/01.ftd.0000198537.41835.71
Keywords
atropine adulterated cocaine; HPLC-MS/MS; human serum analysis; intoxication
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An unexpectedly high number of initially suspected cocaine-intoxicated patients was presented to a general hospital in Lelystad, The Netherlands. Based on the unusual toxidram rate of not fitting cocaine intoxication, the suspicion of co-presence of an anticholinergic agent was raised. A newly developed HPLC-MS/MS analytical method revealed the presence of 10% atropine in a cocaine sample retrieved and subsequently in the sera of 6 intoxicated patients.
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