Journal
AMERICAN JOURNAL OF CLINICAL PATHOLOGY
Volume 125, Issue 6, Pages 860-865Publisher
OXFORD UNIV PRESS INC
DOI: 10.1309/H5UW6CPCWWC92241
Keywords
epidermal growth factor receptor; EGFR; amplification; lung carcinoma
Categories
Ask authors/readers for more resources
We evaluated epidermal growth factor receptor (EGFR) protein expression by immunohistochemical analysis and EGFR gene amplification by fluorescence in situ hybridization in 199 consecutive newly diagnosed and surgically treated patients with primary non-small cell lung carcinoma (NSCLC) and correlated results with clinicopathologic findings. EGFR protein expression was more common in squamous cell carcinoma (SCC; 17 [26.2%]) than in adenocarcinoma (14 [11.1%]; P =.0076) and more frequently associated with EGFR amplification (8 [14.5%] vs 4 [3.6%] cases; P =.0208). Poor differentiation was associated with a higher average number of EGFR gene copies per cell (mean, 4.18; P =.0322) and a higher EGFR/chromosome 7 ratio (mean, 1.84; P =.0324). NO disease showed a higher number of EGFR gene copies (mean, 4.196; P =.0163). SCCs demonstrated a higher EGFR/chromosome 7 ratio than adenocarcinomas (mean, 1.95 vs 1.47; P =.0324), particularly T1 tumors (mean, 1.79; P =.0243). Statistical analysis failed to show correlation between outcome and EGFR protein expression and gene amplification in early NSCLC. EGFR protein expression was uncoupled from gene amplification in most cases, although good correlation occurred in a subset of SM.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available