Journal
CELL CYCLE
Volume 5, Issue 11, Pages 1217-1222Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/cc.5.11.2802
Keywords
cyclin D; cyclin E1; protein kinase A-anchoring protein 95 (AKAP95); PKA; cAMP
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The mechanisms by which cyclins promote mammalian cell cycle progression have been a topic of intense investigation over the last decade. We previously described an interaction between D-type cyclins and A-kinase anchoring protein, AKAP95. Here, we demonstrate that AKAP95 can also bind cyclin E1. Association between AKAP95 and cyclins is displaced by CDKs. We show that these G(1)/S cyclins can interact with RII subunit of PKA alpha through AKAP95. The presence of alternate complexes cyclin-CDK and cyclin D/E-AKAP95-PKA. RII alpha suggest different roles of G(1)/S cyclins and a wider biological importance of these interactions in cells.
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