Journal
BIOMATERIALS
Volume 27, Issue 17, Pages 3163-3167Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2006.01.050
Keywords
in vivo tissue engineering; bone regeneration; replacement; bioreactor; mandible reconstruction; BMP
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In 2004, we reported it novel method of repairing a human mandible by in vivo tissue engineering. The patient served as his own bioreactor as the exogenously prepared customized mandible replacement was grown inside his latissimus dorsi muscle prior to transplantation to repair the existing defect. Our technique was developed through extensive experience with an animal model. We describe our and the patient's experiences with this procedure. We give details to the benefits and limitations of this technique as it stands and outline issues that should be addressed in future human clinical trials. (c) 2006 Elsevier Ltd. All rights reserved.
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