Journal
BRITISH JOURNAL OF HAEMATOLOGY
Volume 133, Issue 5, Pages 530-532Publisher
WILEY
DOI: 10.1111/j.1365-2141.2006.06068.x
Keywords
bone marrow; flow cytometry; multiple myeloma; plasma cells
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Funding
- NIGMS NIH HHS [U54 GM 64346] Funding Source: Medline
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A basic criterion for the diagnosis of multiple myeloma is plasma cell enumeration within the bone marrow (BM). This report showed that flow cytometry under-estimated the number of plasma cells in BM aspirates by an average of 60%, compared with morphological evaluation. The discrepancy was partially because BM smears contain cells associated with the lipid-enriched spicules. In contrast, flow cytometry is performed on the BM fluid, which is depleted of the lipid-adhesive plasma cells. This discrepancy may point to different plasma cell subpopulations associated with diverse niches within the BM.
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