Journal
EXPERIMENTAL NEUROLOGY
Volume 199, Issue 2, Pages 427-437Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.expneurol.2006.01.007
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Funding
- NICHD NIH HHS [1P01-HD-39768-02] Funding Source: Medline
- NIDDK NIH HHS [R01 DK068566, R01 DK068566-03, R01 DK068566-01, 1R01-DK-068566-01, R01 DK068566-04A2, R56 DK068566, R56 DK068566-04A1, R01 DK068566-02] Funding Source: Medline
- NINDS NIH HHS [1R01-NS-045078-01] Funding Source: Medline
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The effects of 8-OH-DPAT (5-HT1A receptor agonist) and WAY100635 (5-HTIA receptor antagonist) on reflex bladder activity were investigated in a-chloralose anesthetized or conscious chronic spinal cord injured cats. The results were similar in both anesthetized and conscious animals. Cystometrograms revealed that 8-OH-DPAT (0.5 mg/kg, s.c.) significantly increased the bladder volume threshold for eliciting a large amplitude micturition contraction, but only slightly reduced the amplitude of the contractions and did not alter the small amplitude pre-micturition contractions. 8-OH-DPAT also reduced the amplitude of isovolumetric bladder contractions. The inhibitory effect of 8-OH-DPAT was reversed by WAY100635 (0.5 mg/kg) or blocked by pre-treatment with WAY100635. Reflex bladder contractions evoked by tactile stimulation of the perigenital region were not altered by S-OH-DPAT. These results suggest that the inhibitory effect of 8-OH-DPAT is mediated by an action on interneuronal pathways in the spinal cord or on the C-fiber afferent limb of the spinal micturition reflex and not on bladder smooth muscle or the efferent limb of the reflex pathway. Drugs that activate 5-HTIA receptors might be useful in treating detrusor overactivity after spinal cord injury. (c) 2006 Elsevier Inc. All rights reserved.
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