Journal
GENES & DEVELOPMENT
Volume 20, Issue 11, Pages 1511-1524Publisher
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/gad.377106
Keywords
neurogenesis; neurogenin; radial migration; RhoA; electroporation; RNA interference
Categories
Funding
- MRC [G0500101, MC_U117570528] Funding Source: UKRI
- Medical Research Council [MC_U117570528, G0500101] Funding Source: researchfish
- Medical Research Council [MC_U117570528, G0500101] Funding Source: Medline
Ask authors/readers for more resources
The generation of neurons by progenitor cells involves the tight coordination of multiple cellular activities, including cell cycle exit, initiation of neuronal differentiation, and cell migration. The mechanisms that integrate these different events into a coherent developmental program are not well understood. Here we show that the cyclin-dependent kinase inhibitor p27(kip1) plays an important role in neurogenesis in the mouse cerebral cortex by promoting the differentiation and radial migration of cortical projection neurons. Importantly, these two functions of p27(Kip1) involve distinct activities, which are independent of its role in cell cycle regulation. p27(Kip1) promotes neuronal differentiation by stabilizing Neurogenin2 protein, an activity carried by the N-terminal half of the protein. p27(kip1) promotes neuronal migration by blocking RhoA signaling, an activity that resides in its C-terminal half. Thus, p27(Kip1) plays a key role in cortical development, acting as a modular protein that independently regulates and couples multiple cellular pathways' contributing to neurogenesis.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available