Journal
ONCOLOGIST
Volume 11, Issue 6, Pages 681-693Publisher
WILEY
DOI: 10.1634/theoncologist.11-6-681
Keywords
low-grade glioma; astrocytoma; oligodendroglioma
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Low-grade gliomas are a heterogeneous group of neoplasms usually encountered in younger patient, populations. These tumors represent a unique challenge because most patients will survive a decade or more and may be at a higher risk for treatment-related complications. Clinical observations over the years have identified a subset of low-grade gliomas that tends to manifest more aggressive clinical behavior and require earlier, more aggressive intervention. Clinical and molecular parameters may allow better assessment of prognosis and application of risk-adjusted management strategies that may include resection, radiation, or chemotherapy. Improved methods of long-term cognitive and functional assessment are desperately needed in this patient population.
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