Journal
IMMUNOGENETICS
Volume 58, Issue 5-6, Pages 471-473Publisher
SPRINGER
DOI: 10.1007/s00251-006-0104-7
Keywords
IL-18; HIV-1 infection; Brazilian children; promoter polymorphism; single-tube allele-specific PCR
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In our study, we identified a polymorphism (C-607A) in the promoter region of the IL-18 gene that shows different frequencies between human immunodeficiency virus (HIV)-1-infected children and healthy controls in a pediatric Brazilian population. The presence of the -607 C allele correlates to HIV-1 infection and confers an increased risk of infection in subjects carrying the single nucleotide polymorphism.
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