Journal
BEHAVIORAL NEUROSCIENCE
Volume 120, Issue 3, Pages 571-579Publisher
AMER PSYCHOLOGICAL ASSOC
DOI: 10.1037/0735-7044.120.3.571
Keywords
mineralocorticoids; reward; salt appetite; intracranial self-stimulation; sucrose intake
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Funding
- NHLBI NIH HHS [HL14388, HL57472] Funding Source: Medline
- NIDDK NIH HHS [DK66086] Funding Source: Medline
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The authors tested the hypothesis that chronic treatment with a dose of deoxycorticosterone acetate (DOCA) known to elicit a robust sodium appetite can negatively affect the hedonic state of rats. Daily treatment with DOCA with no opportunity to ingest saline produced a rightward shift in the midpoint (effective current 50) of lateral hypothalamic self-stimulation (LHSS) current-response functions and reduced intakes of a palatable sucrose solution. Providing rats with 0.3 M saline during DOCA treatment prevented the rightward shift in LHSS response functions and the decrease in sucrose intake. The authors concluded that a chronic sodium appetite, with no opportunity to attenuate the appetite, can elicit a reduced responsiveness to reward.
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