Journal
ACTA PHARMACOLOGICA SINICA
Volume 27, Issue 6, Pages 754-759Publisher
NATURE PUBLISHING GROUP
DOI: 10.1111/j.1745-7254.2006.00337.x
Keywords
poly(lactic-co-glycolic acid); gelatin; basic fibroblast growth factor; microsphere; delayed-action preparations
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Aim: To construct a sustained drug release system for basic fibroblast growth factor (bFGF). With this special system, bFGF can be used to repair an injured peripheral nerve, injured spinal cord, or as a carrier for other drugs that need to be released over a long time. Methods: Microsphere composite was prepared by encapsulating bFGF into gelatin particles with poly(lactic-co-glycolic acid) (PLGA) as its outer-coating. The encapsulation was conducted by a phase separation method. Results: The average diameter of the gelatin particle-PLGA microsphere composite was 5-18 um, and bFGF-loading efficiency was up to 80.5%. The bFGF releasing experiment indicated that this new composite system could release bFGF continuously and protect bFGF from denaturation. Conclusion: A modified approach was successfully employed to develop a biodegradable system for sustained release of the drug of bFGF in vitro.
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