Journal
JOURNAL OF PHARMACOLOGICAL SCIENCES
Volume 101, Issue 2, Pages 118-125Publisher
JAPANESE PHARMACOLOGICAL SOC
DOI: 10.1254/jphs.FP0060135
Keywords
Kampo medicine; eppikahangeto; Ephedrae herba; antitussive effect; laryngeal cough
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To evaluate the efficacy of three common antitussive Kampo formulas, eppikahangeto (EPP), bakumondoto (BAK), and shoseiryutogomakyokansekito (SGM), a new cough model of guinea pig was used, which could specifically induce a laryngeal cough by microinjection of citric acid solution into the larynx. Kampo extract was dissolved in water and the animals were given access ad libitum for 3 days, and then the number of coughs during 10 min was counted. EPP extract decreased the number of coughs dose-dependently (0.3% extract, -22.9 +/- 6.6%, P < 0.01; 1.0% extract, -32.4 +/- 5.5%, P < 0.01). BAK extract and SGM extract had no significant effect. Intraperitoneal injection of codeine (60 mg/kg) also decreased the number of coughs (-36.1 +/- 9.1%, P < 0.05). Furthermore, Ephedrae herba (EH) extract reduced the number of coughs (-18.3 +/- 6.0%, P < 0.05), but the extract of EPP without EH did not. These results suggest that EPP has an antitussive effect against laryngeally-induced cough in guinea pigs, and the crucial herbal medicine is EH.
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