Journal
NATURE IMMUNOLOGY
Volume 7, Issue 6, Pages 563-567Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ni1352
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- NIGMS NIH HHS [GM071408] Funding Source: Medline
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RNA interference constitutes a key component of the innate immune response to viral infection in both plants and invertebrate animals and has been postulated to have a similar protective function in mammals. This perspective reviews the available data addressing whether RNA interference forms part of the mammalian innate immune response and concludes that the popular hypothesis in favor of that possibility remains far from proven and may not be valid.
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